Evidence of jaagsiekte sheep retrovirus-induced pulmonary adenocarcinoma in Ouled Djellal breed sheep in Algeria

Analysis of integration sites of Jaagsiekte sheep retrovirus in ovine pulmonary adenocarcinoma.

Ovine pulmonary adenocarcinoma (OPA) is an infectious lung tumor of sheep caused by Jaagsiekte sheep retrovirus (JSRV). To test the hypothesis that JSRV insertional mutagenesis is involved in the oncogenesis of OPA, we cloned and characterized 70 independent integration sites from 23 cases of OPA. Multiple integration sites were identified in most tumors. BLAST analysis of the sequences did not...

Jaagsiekte Sheep Retrovirus Biology and Oncogenesis

Jaagsiekte sheep retrovirus (JSRV) is the causative agent of a lung cancer in sheep known as ovine pulmonary adenocarcinoma (OPA). The disease has been identified around the world in several breeds of sheep and goats, and JSRV infection typically has a serious impact on affected flocks. In addition, studies on OPA are an excellent model for human lung carcinogenesis. A unique feature of JSRV is...

First case report of enzootic nasal adenocarcinoma in “Ouled Djellal” ewe in Algeria

We report clinical and pathological features of enzootic nasal adenocarcinoma (ENA) in one sheep in Algeria. A one-year-old Ouled Djellal sheep from a large herd (~1240 animals), located in Bordj Bou Arreridj, Algeria, was clinically diagnosed by the presence of persistent seromucous nasal discharge, head shaking, muzzle licking, dyspnoea, exophthalmia and frontal protrusion. The sheep was euth...

Chromosomal distribution of endogenous Jaagsiekte sheep retrovirus proviral sequences in the sheep genome.

A family of endogenous retroviruses (enJSRV) closely related to Jaagsiekte sheep retrovirus (JSRV) is ubiquitous in domestic and wild sheep and goats. Southern blot hybridization studies indicate that there is little active replication or movement of the enJSRV proviruses in these species. Two approaches were used to investigate the distribution of proviral loci in the sheep genome. Fluorescenc...

Sufficient To Induce Lung Tumors in Sheep Retrovirus Envelope Glycoprotein Is Expression of the Jaagsiekte Sheep

Expression of the jaagsiekte sheep retrovirus envelope glycoprotein is sufficient to induce lung tumors in sheep.

Jaagsiekte sheep retrovirus (JSRV) is the causative agent of ovine pulmonary adenocarcinoma (OPA). The expression of the JSRV envelope (Env) alone is sufficient to transform a variety of cell lines in vitro and induce lung cancer in immunodeficient mice. In order to determine the role of the JSRV Env in OPA tumorigenesis in sheep, we derived a JSRV replication-defective virus (JS-RD) which expr...